Endocrine Abstracts

Wnt/beta-catenin signalling pathway is required during embryonic development for normal cell proliferation, differentiation and for organ homeostasis in adulthood. Over-activation of this pathway has been implicated in human cancers such as colon or skin cancers. Here, we demonstrate that enhancement of the Wnt pathway in the embryonic Rathke’s pouch causes over-proliferation of progenitor cells and severe differentiation defects in the Pit1-lineage, which results ...